Optimization of the 4-anilinoquin(az)oline scaffold as epidermal growth factor receptor (EGFR) inhibitors for chordoma utilizing a toxicology profiling assay platform

The 4-anilinoquin(az)oline is a well-known kinase inhibitor scaffold incorporated in clinical inhibitors including gefitinib, erlotinib, afatinib, and lapatinib, all of which have previously demonstrated activity against chordoma cell lines in vitro. We screened a focused array of compounds based on...

Descripción completa

Detalles Bibliográficos
Autores principales: Bieberich, Andrew A., Laitinen, Tuomo, Maffuid, Kaitlyn, Fatig, Raymond O., Torrice, Chad D., Morris, David C., Crona, Daniel J., Asquith, Christopher R. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329436/
https://www.ncbi.nlm.nih.gov/pubmed/35896603
http://dx.doi.org/10.1038/s41598-022-15552-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329436/
https://www.ncbi.nlm.nih.gov/pubmed/35896603
http://dx.doi.org/10.1038/s41598-022-15552-5

Ejemplares similares