Regulation of TIA-1 Condensates: Zn(2+) and RGG Motifs Promote Nucleic Acid Driven LLPS and Inhibit Irreversible Aggregation

Stress granules are non-membrane bound RNA-protein granules essential for survival during acute cellular stress. TIA-1 is a key protein in the formation of stress granules that undergoes liquid-liquid phase separation by association with specific RNAs and protein-protein interactions. However, the f...

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Detalles Bibliográficos
Autores principales: West, Danella L., Loughlin, Fionna E., Rivero-Rodríguez, Francisco, Vankadari, Naveen, Velázquez-Cruz, Alejandro, Corrales-Guerrero, Laura, Díaz-Moreno, Irene, Wilce, Jacqueline A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329571/
https://www.ncbi.nlm.nih.gov/pubmed/35911965
http://dx.doi.org/10.3389/fmolb.2022.960806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329571/
https://www.ncbi.nlm.nih.gov/pubmed/35911965
http://dx.doi.org/10.3389/fmolb.2022.960806

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