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Regulation of TIA-1 Condensates: Zn(2+) and RGG Motifs Promote Nucleic Acid Driven LLPS and Inhibit Irreversible Aggregation
Stress granules are non-membrane bound RNA-protein granules essential for survival during acute cellular stress. TIA-1 is a key protein in the formation of stress granules that undergoes liquid-liquid phase separation by association with specific RNAs and protein-protein interactions. However, the f...
Autores principales: | West, Danella L., Loughlin, Fionna E., Rivero-Rodríguez, Francisco, Vankadari, Naveen, Velázquez-Cruz, Alejandro, Corrales-Guerrero, Laura, Díaz-Moreno, Irene, Wilce, Jacqueline A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329571/ https://www.ncbi.nlm.nih.gov/pubmed/35911965 http://dx.doi.org/10.3389/fmolb.2022.960806 |
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