Copper (I)-Chloroquine Complexes: Interactions with DNA and Ferriprotoporphyrin, Inhibition of β-Hematin Formation and Relation to Antimalarial Activity

A new Cu(I)-chloroquine (CQ) complex [Cu(CQ)(PPh(3))(2)]NO(3) (1) was synthesized and characterized, and its mechanism of action studied concomitant with the previously reported complex [Cu(CQ)(2)]Cl (2). These copper (I) coordination compounds can be considered as potential antimalarial agents beca...

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Detalles Bibliográficos
Autores principales: Villarreal, Wilmer, Castro, William, González, Sorenlis, Madamet, Marylin, Amalvict, Rémy, Pradines, Bruno, Navarro, Maribel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329717/
https://www.ncbi.nlm.nih.gov/pubmed/35893745
http://dx.doi.org/10.3390/ph15080921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329717/
https://www.ncbi.nlm.nih.gov/pubmed/35893745
http://dx.doi.org/10.3390/ph15080921

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