Modulation of Primary Cilia by Alvocidib Inhibition of CILK1

The primary cilium provides cell sensory and signaling functions. Cilia structure and function are regulated by ciliogenesis-associated kinase 1 (CILK1). Ciliopathies caused by CILK1 mutations show longer cilia and abnormal Hedgehog signaling. Our study aimed to identify small molecular inhibitors o...

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Detalles Bibliográficos
Autores principales: Wang, Elena X., Turner, Jacob S., Brautigan, David L., Fu, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329819/
https://www.ncbi.nlm.nih.gov/pubmed/35897693
http://dx.doi.org/10.3390/ijms23158121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329819/
https://www.ncbi.nlm.nih.gov/pubmed/35897693
http://dx.doi.org/10.3390/ijms23158121

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