Cargando…

Newly Synthesized Pyrazolinone Chalcones as Anticancer Agents via Inhibiting the PI3K/Akt/ERK1/2 Signaling Pathway

[Image: see text] A series of novel pyrazolinone chalcones 3–9 have been synthesized through the condensation of azo pyrazolinone derivatives with various aromatic aldehydes. Spectroscopic techniques and elemental analysis have both corroborated this. Furthermore, all compounds were screened in sili...

Descripción completa

Detalles Bibliográficos
Autores principales:	Noser, Ahmed A., Shehadi, Ihsan A., Abdelmonsef, Aboubakr H., Salem, Maha M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330109/ https://www.ncbi.nlm.nih.gov/pubmed/35910116 http://dx.doi.org/10.1021/acsomega.2c02181

Ejemplares similares

Synthesis, In Silico and In Vitro Assessment of New Quinazolinones as Anticancer Agents via Potential AKT Inhibition
por: Noser, Ahmed A., et al.
Publicado: (2020)

New Amino Acid Schiff Bases as Anticancer Agents via Potential Mitochondrial Complex I-Associated Hexokinase Inhibition and Targeting AMP-Protein Kinases/mTOR Signaling Pathway
por: Noser, Ahmed A., et al.
Publicado: (2021)

Synthesis, Molecular Docking Analysis and in Vitro Biological Evaluation of Some New Heterocyclic Scaffolds-Based Indole Moiety as Possible Antimicrobial Agents
por: Hassan, Entesar A., et al.
Publicado: (2022)

Homology Modeling and Virtual Screening Studies of Antigen MLAA-42 Protein: Identification of Novel Drug Candidates against Leukemia—An In Silico Approach
por: Shehadi, Ihsan A., et al.
Publicado: (2020)

Antimicrobial Potency and E. coli β-Carbonic Anhydrase Inhibition Efficacy of Phenazone-Based Molecules
por: Rashdan, Huda R. M., et al.
Publicado: (2023)

Synthesis, Anticancer Evaluation, Computer-Aided Docking Studies, and ADMET Prediction of 1,2,3-Triazolyl-Pyridine Hybrids as Human Aurora B Kinase Inhibitors
por: Rashdan, Huda R.M., et al.
Publicado: (2021)

Synthesis, molecular docking, and in-vitro studies of pyrimidine-2-thione derivatives as antineoplastic agents via potential RAS/PI3K/Akt/JNK inhibition in breast carcinoma cells
por: Salem, Maha M., et al.
Publicado: (2022)

Design and biological evaluation of 3-substituted quinazoline-2,4(1H,3H)-dione derivatives as dual c-Met/VEGFR-2-TK inhibitors
por: Hassan, Abdelfattah, et al.
Publicado: (2023)

Synthesis, Molecular Docking Screening and Anti-Proliferative Potency Evaluation of Some New Imidazo[2,1-b]Thiazole Linked Thiadiazole Conjugates
por: Rashdan, Huda R. M., et al.
Publicado: (2020)

Synthesis of chalcone incorporated quinazoline derivatives as anticancer agents
por: Madhavi, Sapavat, et al.
Publicado: (2017)

Synthesis and evaluation of new chalcones and oximes as anticancer agents
por: Bukhari, Syed Nasir Abbas
Publicado: (2022)

Cyclization of Chalcone Derivatives: Design, Synthesis, In Silico Docking Study, and Biological Evaluation of New Quinazolin-2,4-diones Incorporating Five-, Six-, and Seven-Membered Ring Moieties as Potent Antibacterial Inhibitors
por: El-Naggar, Mohamed, et al.
Publicado: (2023)

Synthesis of Novel 3H-Quinazolin-4-ones Containing Pyrazolinone, Pyrazole and Pyrimidinone Moieties
por: Saleh, Mohamed A., et al.
Publicado: (2003)

Newly-synthesized chalcones-inhibition of adherence and biofilm formation of methicillin-resistant Staphylococcus aureus
por: Bozic, Dragana D., et al.
Publicado: (2014)

Design and Synthesis of Benzimidazole-Chalcone Derivatives as Potential Anticancer Agents
por: Hsieh, Cheng-Ying, et al.
Publicado: (2019)

Design, synthesis and antiproliferative screening of newly synthesized acrylate derivatives as potential anticancer agents
por: Alshaya, Dalal Sulaiman, et al.
Publicado: (2023)

Synthesis of Novel Chalcone-Based Phenothiazine Derivatives as Antioxidant and Anticancer Agents
por: Al Zahrani, Nourah A., et al.
Publicado: (2020)

Synthesis of Chalcones with Anticancer Activities
por: Syam, Suvitha, et al.
Publicado: (2012)

Synthesis and Biological Activity Screening of Newly Synthesized Trimethoxyphenyl-Based Analogues as Potential Anticancer Agents
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

Newly Synthesized Water Soluble Cholinium-Purpurin Photosensitizers and Their Stabilized Gold Nanoparticles as Promising Anticancer Agents
por: Demberelnyamba, Dorjnamjin, et al.
Publicado: (2008)

Anticancer Activity of Natural and Synthetic Chalcones
por: Constantinescu, Teodora, et al.
Publicado: (2021)

Chalcone Derivatives: Role in Anticancer Therapy
por: Ouyang, Yang, et al.
Publicado: (2021)

Anticancer Activities of Newly Synthesized Chiral Macrocyclic Heptapeptide Candidates
por: Abo-Ghalia, Mohamed H., et al.
Publicado: (2020)

In vitro nephrotoxicity and anticancer potency of newly synthesized cadmium complexes
por: Abyar, Selda, et al.
Publicado: (2019)

α-Trifluoromethyl Chalcones as Potent Anticancer Agents for Androgen Receptor-Independent Prostate Cancer
por: Saito, Yohei, et al.
Publicado: (2021)

Synthesis, Molecular Docking Studies and In Silico ADMET Screening of New Heterocycles Linked Thiazole Conjugates as Potent Anti-Hepatic Cancer Agents
por: Rashdan, Huda R. M., et al.
Publicado: (2021)

Antibacterial activity of three newly-synthesized chalcones & synergism with antibiotics against clinical isolates of methicillin-resistant Staphylococcus aureus
por: Božić, Dragana D., et al.
Publicado: (2014)

In Vitro Antioxidant Activities and the Therapeutic Potential of Some Newly Synthesized Chalcones Against 4-Acetaminophenol Induced Hepatotoxicity in Rats
por: Akhtar, Muhammad Shoaib, et al.
Publicado: (2021)

Coumaro-chalcones synthesized under solvent-free conditions as potential agents against malaria, leishmania and trypanosomiasis
por: Cuellar, José E., et al.
Publicado: (2022)

Chalcone Scaffold in Anticancer Armamentarium: A Molecular Insight
por: Das, Manik, et al.
Publicado: (2016)

Enhancement of Anticancer Potential of Pterostilbene Derivative by Chalcone Hybridization
por: Tang, Kai-Wei, et al.
Publicado: (2021)

Two Important Anticancer Mechanisms of Natural and Synthetic Chalcones
por: Constantinescu, Teodora, et al.
Publicado: (2022)

Anticancer Potential of Natural Chalcones: In Vitro and In Vivo Evidence
por: Michalkova, Radka, et al.
Publicado: (2023)

Newly synthesized anticancer drug HUHS1015 is effective on malignant pleural mesothelioma
por: Kaku, Yoshiko, et al.
Publicado: (2014)

In Silico Screening and Anticancer-Apoptotic Evaluation of Newly Synthesized Thienopyrimidine/Sulfonamide Hybrids
por: Elmongy, Elshaymaa I., et al.
Publicado: (2023)

The newly synthesized anticancer drug HUHS1015 is useful for treatment of human gastric cancer
por: Kaku, Yoshiko, et al.
Publicado: (2015)

In silico study to identify novel potential thiadiazole-based molecules as anti-Covid-19 candidates by hierarchical virtual screening and molecular dynamics simulations
por: Rashdan, Huda R. M., et al.
Publicado: (2022)

Synthesis and Anticancer Activity Assay of Novel Chalcone-Sulfonamide Derivatives
por: Pesaran Seiied Bonakdar, Ahmad, et al.
Publicado: (2017)

Anticancer Indole-Based Chalcones: A Structural and Theoretical Analysis
por: Badria, Farid A., et al.
Publicado: (2019)

Anticancer Activity of Chalcones and Its Derivatives: Review and In Silico Studies
por: Leite, Fernando Ferreira, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_esd6bb8lk8p2a60uch8n3kqq12