Discovery of pH-Selective Marine and Plant Natural Product Inhibitors of Cathepsin B Revealed by Screening at Acidic and Neutral pH Conditions

[Image: see text] Dysregulation of cathepsin B, which involves the translocation of the enzyme from acidic pH lysosomes to the neutral pH cytosol, followed by the initiation of cell death and inflammation, occurs in numerous brain disorders. The wide difference in the acidic pH (4.6) of lysosomes co...

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Detalles Bibliográficos
Autores principales: Phan, Von V., Mosier, Charles, Yoon, Michael C., Glukhov, Evgenia, Caffrey, Conor R., O’Donoghue, Anthony J., Gerwick, William H., Hook, Vivian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330179/
https://www.ncbi.nlm.nih.gov/pubmed/35910167
http://dx.doi.org/10.1021/acsomega.2c02287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330179/
https://www.ncbi.nlm.nih.gov/pubmed/35910167
http://dx.doi.org/10.1021/acsomega.2c02287

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