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Recurrent Novel P2RY8/IGH Translocations in B-Lymphoblastic Leukemia/Lymphoma
Translocations involving the immunoglobulin heavy chain (IGH) locus are common abnormalities in B-lymphoblastic leukemia/lymphoma (B-ALL) and multiple myeloma. These rearrangements result in a juxtaposition of IGH enhancers to the vicinity of oncogenes, such as MYC and CRLF2, leading to the upregula...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330356/ https://www.ncbi.nlm.nih.gov/pubmed/35912172 http://dx.doi.org/10.3389/fonc.2022.896858 |
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author | Fang, Yanglan Wang, Man Hu, Shuhong Wang, Tanzhen Liu, Yujie Xiao, Jinyan Cai, Yiming Wang, Ying Qiu, Huiying Tang, Xiaowen Chen, Suning Wu, Depei Xu, Yang Liu, Tianhui |
author_facet | Fang, Yanglan Wang, Man Hu, Shuhong Wang, Tanzhen Liu, Yujie Xiao, Jinyan Cai, Yiming Wang, Ying Qiu, Huiying Tang, Xiaowen Chen, Suning Wu, Depei Xu, Yang Liu, Tianhui |
author_sort | Fang, Yanglan |
collection | PubMed |
description | Translocations involving the immunoglobulin heavy chain (IGH) locus are common abnormalities in B-lymphoblastic leukemia/lymphoma (B-ALL) and multiple myeloma. These rearrangements result in a juxtaposition of IGH enhancers to the vicinity of oncogenes, such as MYC and CRLF2, leading to the upregulation of oncogenes. Here, we identified recurrent novel P2RY8/IGH translocations in three B-ALL patients by transcriptome sequencing. Noncoding exon 1 of P2RY8 was translocated to different sites of the IGH gene, resulting in transcripts of P2RY8/IGHM, P2RY8/IGHV, and P2RY8/IGHD. However, a high expression level of truncated P2RY8 was observed in the patients compared with healthy donors, which might be related to the aggressive clinical course and inferior outcome. In summary, we described recurrent novel P2RY8/IGH translocations with high expression levels of P2RY8, which may contribute to the guidelines for clinical diagnosis and treatment. |
format | Online Article Text |
id | pubmed-9330356 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93303562022-07-29 Recurrent Novel P2RY8/IGH Translocations in B-Lymphoblastic Leukemia/Lymphoma Fang, Yanglan Wang, Man Hu, Shuhong Wang, Tanzhen Liu, Yujie Xiao, Jinyan Cai, Yiming Wang, Ying Qiu, Huiying Tang, Xiaowen Chen, Suning Wu, Depei Xu, Yang Liu, Tianhui Front Oncol Oncology Translocations involving the immunoglobulin heavy chain (IGH) locus are common abnormalities in B-lymphoblastic leukemia/lymphoma (B-ALL) and multiple myeloma. These rearrangements result in a juxtaposition of IGH enhancers to the vicinity of oncogenes, such as MYC and CRLF2, leading to the upregulation of oncogenes. Here, we identified recurrent novel P2RY8/IGH translocations in three B-ALL patients by transcriptome sequencing. Noncoding exon 1 of P2RY8 was translocated to different sites of the IGH gene, resulting in transcripts of P2RY8/IGHM, P2RY8/IGHV, and P2RY8/IGHD. However, a high expression level of truncated P2RY8 was observed in the patients compared with healthy donors, which might be related to the aggressive clinical course and inferior outcome. In summary, we described recurrent novel P2RY8/IGH translocations with high expression levels of P2RY8, which may contribute to the guidelines for clinical diagnosis and treatment. Frontiers Media S.A. 2022-07-14 /pmc/articles/PMC9330356/ /pubmed/35912172 http://dx.doi.org/10.3389/fonc.2022.896858 Text en Copyright © 2022 Fang, Wang, Hu, Wang, Liu, Xiao, Cai, Wang, Qiu, Tang, Chen, Wu, Xu and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Fang, Yanglan Wang, Man Hu, Shuhong Wang, Tanzhen Liu, Yujie Xiao, Jinyan Cai, Yiming Wang, Ying Qiu, Huiying Tang, Xiaowen Chen, Suning Wu, Depei Xu, Yang Liu, Tianhui Recurrent Novel P2RY8/IGH Translocations in B-Lymphoblastic Leukemia/Lymphoma |
title | Recurrent Novel P2RY8/IGH Translocations in B-Lymphoblastic Leukemia/Lymphoma |
title_full | Recurrent Novel P2RY8/IGH Translocations in B-Lymphoblastic Leukemia/Lymphoma |
title_fullStr | Recurrent Novel P2RY8/IGH Translocations in B-Lymphoblastic Leukemia/Lymphoma |
title_full_unstemmed | Recurrent Novel P2RY8/IGH Translocations in B-Lymphoblastic Leukemia/Lymphoma |
title_short | Recurrent Novel P2RY8/IGH Translocations in B-Lymphoblastic Leukemia/Lymphoma |
title_sort | recurrent novel p2ry8/igh translocations in b-lymphoblastic leukemia/lymphoma |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330356/ https://www.ncbi.nlm.nih.gov/pubmed/35912172 http://dx.doi.org/10.3389/fonc.2022.896858 |
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