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Genetic Diversity and Low Therapeutic Impact of Variant-Specific Markers in HIV-1 Pol Proteins

The emergence and spread of new HIV-1 variants pose a challenge for the effectiveness of antiretrovirals (ARV) targeting Pol proteins. During viral evolution, non-synonymous mutations have fixed along the viral genome, leading to amino acid (aa) changes that can be variant-specific (V-markers). Thos...

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Detalles Bibliográficos
Autores principales: Troyano-Hernáez, Paloma, Reinosa, Roberto, Holguín, Africa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330395/
https://www.ncbi.nlm.nih.gov/pubmed/35910645
http://dx.doi.org/10.3389/fmicb.2022.866705