Optimized Replacement T4 and T4+T3 Dosing in Male and Female Hypothyroid Patients With Different BMIs Using a Personalized Mechanistic Model of Thyroid Hormone Regulation Dynamics

OBJECTIVE: A personalized simulation tool, p-THYROSIM, was developed (1) to better optimize replacement LT4 and LT4+LT3 dosing for hypothyroid patients, based on individual hormone levels, BMIs, and gender; and (2) to better understand how gender and BMI impact thyroid dynamical regulation over time...

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Detalles Bibliográficos
Autores principales: Cruz-Loya, Mauricio, Chu, Benjamin B., Jonklaas, Jacqueline, Schneider, David F., DiStefano, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330449/
https://www.ncbi.nlm.nih.gov/pubmed/35909562
http://dx.doi.org/10.3389/fendo.2022.888429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330449/
https://www.ncbi.nlm.nih.gov/pubmed/35909562
http://dx.doi.org/10.3389/fendo.2022.888429

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