EZH2 inhibition activates dsRNA-interferon axis stress and promotes response to PD-1 checkpoint blockade in NSCLC

Lung cancer is the leading cause of cancer death and immunotherapy had been approved be a useful approach for NSCLC therapy. However, only part of the patients responds to checkpoint inhibitors. The EZH2, as a histone modification regulator, is overexpressed in NSCLC and negatively regulates the int...

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Detalles Bibliográficos
Autores principales: Qiu, Fengqi, Yang, Qi, Sun, Wenjia, Ruan, Kexin, Jiang, Nan, Zhou, Jianya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330466/
https://www.ncbi.nlm.nih.gov/pubmed/35912007
http://dx.doi.org/10.7150/jca.73291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330466/
https://www.ncbi.nlm.nih.gov/pubmed/35912007
http://dx.doi.org/10.7150/jca.73291

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