Inhibition of Ubiquitin-Specific Protease-13 Improves Behavioral Performance in Alpha-Synuclein Expressing Mice

Ubiquitin-Specific Protease-13 (USP13) promotes protein de-ubiquitination. USP13 levels are upregulated in post-mortem Parkinson’s disease, whereas USP13 knockdown via shRNA reduces alpha-synuclein levels in animal models. We studied the role of USP13 in knockout mice expressing lentiviral human alp...

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Detalles Bibliográficos
Autores principales: Liu, Xiaoguang, Balaraman, Kaluvu, Lynch, Ciarán C., Hebron, Michaeline, Shah, Priya Ketankumar, Hu, Shicheng, Stevenson, Max, Wolf, Christian, Moussa, Charbel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330474/
https://www.ncbi.nlm.nih.gov/pubmed/35897705
http://dx.doi.org/10.3390/ijms23158131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330474/
https://www.ncbi.nlm.nih.gov/pubmed/35897705
http://dx.doi.org/10.3390/ijms23158131

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