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Inhibition of Ubiquitin-Specific Protease-13 Improves Behavioral Performance in Alpha-Synuclein Expressing Mice

Ubiquitin-Specific Protease-13 (USP13) promotes protein de-ubiquitination. USP13 levels are upregulated in post-mortem Parkinson’s disease, whereas USP13 knockdown via shRNA reduces alpha-synuclein levels in animal models. We studied the role of USP13 in knockout mice expressing lentiviral human alp...

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Detalles Bibliográficos
Autores principales:	Liu, Xiaoguang, Balaraman, Kaluvu, Lynch, Ciarán C., Hebron, Michaeline, Shah, Priya Ketankumar, Hu, Shicheng, Stevenson, Max, Wolf, Christian, Moussa, Charbel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330474/ https://www.ncbi.nlm.nih.gov/pubmed/35897705 http://dx.doi.org/10.3390/ijms23158131

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