A Novel Dimeric Conotoxin, FrXXA, from the Vermivorous Cone Snail Conus fergusoni, of the Eastern Pacific, Inhibits Nicotinic Acetylcholine Receptors

We isolated a new dimeric conotoxin with inhibitory activity against neuronal nicotinic acetylcholine receptors. Edman degradation and transcriptomic studies indicate a homodimeric conotoxin composed by two chains of 47 amino acid in length. It has the cysteine framework XX and 10 disulfide bonds. A...

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Detalles Bibliográficos
Autores principales: Rodriguez-Ruiz, Ximena C., Aguilar, Manuel B., Ortíz-Arellano, Mónica A., Safavi-Hemami, Helena, López-Vera, Estuardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330476/
https://www.ncbi.nlm.nih.gov/pubmed/35893752
http://dx.doi.org/10.3390/toxins14080510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330476/
https://www.ncbi.nlm.nih.gov/pubmed/35893752
http://dx.doi.org/10.3390/toxins14080510

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