Microbial metabolite restricts 5-fluorouracil-resistant colonic tumor progression by sensitizing drug transporters via regulation of FOXO3-FOXM1 axis

The survival rate of colorectal cancer patients is adversely affected by the selection of tumors resistant to conventional anti-cancer drugs such as 5-fluorouracil (5FU). Although there is mounting evidence that commensal gut microbiota is essential for effective colon cancer treatment, the detailed...

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Detalles Bibliográficos
Autores principales: Ghosh, Sweta, Singh, Rajbir, Vanwinkle, Zachary Matthew, Guo, Haixun, Vemula, Praveen Kumar, Goel, Ajay, Haribabu, Bodduluri, Jala, Venkatakrishna Rao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330515/
https://www.ncbi.nlm.nih.gov/pubmed/35910798
http://dx.doi.org/10.7150/thno.70754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330515/
https://www.ncbi.nlm.nih.gov/pubmed/35910798
http://dx.doi.org/10.7150/thno.70754

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