HER2-targeted dual radiotracer approach with clinical potential for noninvasive imaging of trastuzumab-resistance caused by epitope masking

Rationale: The decreased HER2-accessibility by epitope masking is a primary trastuzumab-resistance mechanism. In this study, we developed a HER2-targeted dual radiotracer approach to predict the HER2-trastuzumab engagement noninvasively. Methods: Two novel HER2-specific VHHs, MIRC208 and MIRC213, we...

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Detalles Bibliográficos
Autores principales: Li, Liqiang, Liu, Tianyu, Shi, Linqing, Zhang, Xin, Guo, Xiaoyi, Hu, Biao, Yao, Meinan, Zhu, Hua, Yang, Zhi, Jia, Bing, Wang, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330517/
https://www.ncbi.nlm.nih.gov/pubmed/35910795
http://dx.doi.org/10.7150/thno.74154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330517/
https://www.ncbi.nlm.nih.gov/pubmed/35910795
http://dx.doi.org/10.7150/thno.74154

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