Subpial delivery of adeno-associated virus 9-synapsin-caveolin-1 (AAV9-SynCav1) preserves motor neuron and neuromuscular junction morphology, motor function, delays disease onset, and extends survival in hSOD1(G93A) mice

Elevating neuroprotective proteins using adeno-associated virus (AAV)-mediated gene delivery shows great promise in combating devastating neurodegenerative diseases. Amyotrophic lateral sclerosis (ALS) is one such disease resulting from loss of upper and lower motor neurons (MNs) with 90-95% of case...

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Detalles Bibliográficos
Autores principales: Wang, Shanshan, Ichinomiya, Taiga, Savchenko, Paul, Wang, Dongsheng, Sawada, Atsushi, Li, Xiaojing, Duong, Tiffany, Li, Wenxi, Bonds, Jacqueline A., Kim, Eun Jung, Miyanohara, Atsushi, Roth, David M., Patel, Hemal H., Patel, Piyush M., Tadokoro, Takahiro, Marsala, Martin, Head, Brian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330519/
https://www.ncbi.nlm.nih.gov/pubmed/35910808
http://dx.doi.org/10.7150/thno.72614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330519/
https://www.ncbi.nlm.nih.gov/pubmed/35910808
http://dx.doi.org/10.7150/thno.72614

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