Isolated Variable Domains of an Antibody Can Assemble on Blood Coagulation Factor VIII into a Functional Fv-like Complex

Single-chain variable fragments (scFv) are antigen-recognizing variable fragments of antibodies (FV) where both subunits (V(L) and V(H)) are connected via an artificial linker. One particular scFv, iKM33, directed against blood coagulation factor VIII (FVIII) was shown to inhibit major FVIII functio...

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Detalles Bibliográficos
Autores principales: Shestopal, Svetlana A., Parunov, Leonid A., Olivares, Philip, Chun, Haarin, Ovanesov, Mikhail V., Pettersson, John R., Sarafanov, Andrey G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330781/
https://www.ncbi.nlm.nih.gov/pubmed/35897712
http://dx.doi.org/10.3390/ijms23158134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330781/
https://www.ncbi.nlm.nih.gov/pubmed/35897712
http://dx.doi.org/10.3390/ijms23158134

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