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Cisplatin Effects on the Human Fetal Testis – Establishing the Sensitive Period for (Pre)Spermatogonial Loss and Relevance for Fertility Preservation in Pre-Pubertal Boys
BACKGROUND: Exposure to chemotherapy during childhood can impair future fertility. Studies using in vitro culture have shown exposure to platinum-based alkylating-like chemotherapy reduces the germ cell number in the human fetal testicular tissues. We aimed to determine whether effects of exposure t...
Autores principales: | Matilionyte, Gabriele, Rimmer, Michael P., Spears, Norah, Anderson, Richard A., Mitchell, Rod T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330899/ https://www.ncbi.nlm.nih.gov/pubmed/35909565 http://dx.doi.org/10.3389/fendo.2022.914443 |
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