Impact of Multiple Sclerosis Risk Polymorphism rs7665090 on MANBA Activity, Lysosomal Endocytosis, and Lymphocyte Activation

Deficiencies in Mannosidase β (MANBA) are associated with neurological abnormalities and recurrent infections. The single nucleotide polymorphism located in the 3′UTR of MANBA, rs7665090, was found to be associated with multiple sclerosis (MS) susceptibility. We aimed to study the functional impact...

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Detalles Bibliográficos
Autores principales: González-Jiménez, Adela, López-Cotarelo, Pilar, Agudo-Jiménez, Teresa, Casanova, Ignacio, de Silanes, Carlos López, Martín-Requero, Ángeles, Matesanz, Fuencisla, Urcelay, Elena, Espino-Paisán, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331056/
https://www.ncbi.nlm.nih.gov/pubmed/35897697
http://dx.doi.org/10.3390/ijms23158116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331056/
https://www.ncbi.nlm.nih.gov/pubmed/35897697
http://dx.doi.org/10.3390/ijms23158116

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