Intra-Domain Cysteines (IDC), a New Strategy for the Development of Original Antibody Fragment–Drug Conjugates (FDCs)

Antibody–drug conjugates (ADCs) derived from a full immunoglobulin-G (IgG) are associated with suboptimal solid-tumor penetration and Fc-mediated toxicities. Antibody fragment–drug conjugates (FDCs) could be an alternative. Nevertheless, innovative solutions are needed to implant cysteines as conjug...

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Detalles Bibliográficos
Autores principales: Jolivet, Louis, Ait Mohamed Amar, Imène, Horiot, Catherine, Boursin, Fanny, Colas, Cyril, Letast, Stéphanie, Denevault-Sabourin, Caroline, Allard-Vannier, Emilie, Joubert, Nicolas, Aubrey, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331466/
https://www.ncbi.nlm.nih.gov/pubmed/35893780
http://dx.doi.org/10.3390/pharmaceutics14081524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331466/
https://www.ncbi.nlm.nih.gov/pubmed/35893780
http://dx.doi.org/10.3390/pharmaceutics14081524

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