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Cancer-Associated Mutations of the Adenosine A(2A) Receptor Have Diverse Influences on Ligand Binding and Receptor Functions

The adenosine A(2A) receptor (A(2A)AR) is a class A G-protein-coupled receptor (GPCR). It is an immune checkpoint in the tumor micro-environment and has become an emerging target for cancer treatment. In this study, we aimed to explore the effects of cancer-patient-derived A(2A)AR mutations on ligan...

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Detalles Bibliográficos
Autores principales:	Feng, Chenlin, Wang, Xuesong, Jespers, Willem, Liu, Rongfang, Zamarbide Losada, Sofía Denise, Gorostiola González, Marina, van Westen, Gerard J. P., Danen, Erik H. J., Heitman, Laura H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331671/ https://www.ncbi.nlm.nih.gov/pubmed/35897852 http://dx.doi.org/10.3390/molecules27154676

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