DNA Demethylation Switches Oncogenic ΔNp63 to Tumor Suppressive TAp63 in Squamous Cell Carcinoma

The TP63 gene encodes two major protein variants; TAp63 contains a p53-like transcription domain and consequently has tumor suppressor activities whereas ΔNp63 lacks this domain and acts as an oncogene. The two variants show distinct expression patterns in normal tissues and tumors, with lymphocytes...

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Detalles Bibliográficos
Autores principales: Pokorna, Zuzana, Hrabal, Vaclav, Tichy, Vlastimil, Vojtesek, Borivoj, Coates, Philip J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331744/
https://www.ncbi.nlm.nih.gov/pubmed/35912167
http://dx.doi.org/10.3389/fonc.2022.924354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331744/
https://www.ncbi.nlm.nih.gov/pubmed/35912167
http://dx.doi.org/10.3389/fonc.2022.924354

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