Cargando…

MhcII Regulates Transmission of α-Synuclein-Seeded Pathology in Mice

MHCII molecules, expressed by professional antigen-presenting cells (APCs) such as T cells and B cells, are hypothesized to play a key role in the response of cellular immunity to α-synuclein (α-syn). However, the role of cellular immunity in the neuroanatomic transmission of α-syn pre-formed fibril...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gonzalez De La Cruz, Elsa, Vo, Quan, Moon, Katie, McFarland, Karen N., Weinrich, Mary, Williams, Tristan, Giasson, Benoit I., Chakrabarty, Paramita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332117/ https://www.ncbi.nlm.nih.gov/pubmed/35897751 http://dx.doi.org/10.3390/ijms23158175

Ejemplares similares

Differential cross-seeding properties of tau and α-synuclein in mouse models of tauopathy and synucleinopathy
por: Williams, Tosha, et al.
Publicado: (2020)

Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice
por: Koller, Emily J., et al.
Publicado: (2017)

Impact of APOE genotype on prion-type propagation of tauopathy
por: Williams, Tristan, et al.
Publicado: (2022)

The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome
por: Park, Hyo-Jin, et al.
Publicado: (2017)

Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple system atrophy
por: Hass, Ethan W., et al.
Publicado: (2021)

A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies
por: Dhillon, Jess-Karan S., et al.
Publicado: (2017)

Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity
por: Sorrentino, Zachary A., et al.
Publicado: (2017)

Determinants of seeding and spreading of α-synuclein pathology in the brain
por: Henrich, Martin T., et al.
Publicado: (2020)

Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau
por: Smith, Ethan D., et al.
Publicado: (2023)

MHCII3D—Robust Structure Based Prediction of MHC II Binding Peptides
por: Laimer, Josef, et al.
Publicado: (2020)

α-Synuclein Induces Progressive Changes in Brain Microstructure and Sensory-Evoked Brain Function That Precedes Locomotor Decline
por: Chu, Winston T., et al.
Publicado: (2020)

Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrils
por: Dhillon, Jess-Karan S., et al.
Publicado: (2019)

Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression
por: Sorrentino, Zachary A., et al.
Publicado: (2019)

Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies
por: Uchihara, Toshiki, et al.
Publicado: (2015)

Optical pulse labeling studies reveal exogenous seeding slows α-synuclein clearance
por: Croft, Cara L., et al.
Publicado: (2022)

Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy
por: Williams, Tristan, et al.
Publicado: (2023)

Does a prion-like mechanism play a major role in the apparent spread of α-synuclein pathology?
por: Sacino, Amanda N, et al.
Publicado: (2012)

Il-10 signaling reduces survival in mouse models of synucleinopathy
por: Cockey, Samuel G., et al.
Publicado: (2021)

Targeted proteolytic products of τ and α-synuclein in neurodegeneration
por: Xia, Yuxing, et al.
Publicado: (2021)

T cell infiltration and upregulation of MHCII in microglia leads to accelerated neuronal loss in an α-synuclein rat model of Parkinson’s disease
por: Subbarayan, Meena S., et al.
Publicado: (2020)

Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein
por: Sacino, Amanda N, et al.
Publicado: (2013)

Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways
por: Ibanez, Kristen R., et al.
Publicado: (2022)

DeepMHCII: a novel binding core-aware deep interaction model for accurate MHC-II peptide binding affinity prediction
por: You, Ronghui, et al.
Publicado: (2022)

Fate of MHCII in salmonids following 4WGD
por: Grimholt, Unni, et al.
Publicado: (2020)

Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology
por: Pace, Michael C., et al.
Publicado: (2018)

Novel monoclonal antibodies targeting the microtubule-binding domain of human tau
por: Croft, Cara L., et al.
Publicado: (2018)

Novel antibodies to phosphorylated α-synuclein serine 129 and NFL serine 473 demonstrate the close molecular homology of these epitopes
por: Rutherford, Nicola J., et al.
Publicado: (2016)

Conformational templating of α-synuclein aggregates in neuronal-glial cultures
por: Sacino, Amanda N, et al.
Publicado: (2013)

Endogenous Oligodendroglial Alpha-Synuclein and TPPP/p25α Orchestrate Alpha-Synuclein Pathology in Experimental Multiple System Atrophy Models
por: Mavroeidi, Panagiota, et al.
Publicado: (2019)

Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice
por: Rutherford, Nicola J., et al.
Publicado: (2015)

Cross-seeding of prions by aggregated α-synuclein leads to transmissible spongiform encephalopathy
por: Katorcha, Elizaveta, et al.
Publicado: (2017)

Transmissible α-synuclein seeding activity in brain and stomach of patients with Parkinson’s disease
por: Thomzig, Achim, et al.
Publicado: (2021)

MHCII glycosylation modulates Bacteroides fragilis carbohydrate antigen presentation
por: Ryan, Sean O., et al.
Publicado: (2011)

How MHCII signaling promotes benign host-microbiota interactions
por: Roland, Mary Melissa, et al.
Publicado: (2020)

MHCII-restricted T helper cells: an emerging trigger for chronic tactile allodynia after nerve injuries
por: Ding, You-Quan, et al.
Publicado: (2020)

Characterization of splenic MRC1(hi)MHCII(lo) and MRC1(lo)MHCII(hi) cells from the monocyte/macrophage lineage of White Leghorn chickens
por: Yu, Keesun, et al.
Publicado: (2020)

CD4 T Cells Induce A Subset of MHCII-Expressing Microglia that Attenuates Alzheimer Pathology
por: Mittal, Kritika, et al.
Publicado: (2019)

Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau
por: Strang, Kevin H., et al.
Publicado: (2017)

Protein Transmission, Seeding and Degradation: Key Steps for α-Synuclein Prion-Like Propagation
por: Oueslati, Abid, et al.
Publicado: (2014)

Correction to: Transmissible α‑synuclein seeding activity in brain and stomach of patients with Parkinson’s disease
por: Thomzig, Achim, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_c93e15upuovk9ggiti191qrrpl