Neutrophil Elastase Increases Vascular Permeability and Leukocyte Transmigration in Cultured Endothelial Cells and Obese Mice

Neutrophil elastase (NE) plays a pivotal role in inflammation. However, the mechanism underlying NE-mediated inflammation in obesity remains unclear. Here, we report that NE activates protease-activated receptor-2 (PAR2), stimulates actin filament (F-actin) formation, decreases intercellular junctio...

Descripción completa

Detalles Bibliográficos
Autores principales: Ushakumari, Chinchu Jagadan, Zhou, Qiong L., Wang, Yu-Hua, Na, Sijia, Rigor, Michael C., Zhou, Cindy Y., Kroll, Max K., Lin, Benjamin D., Jiang, Zhen Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332277/
https://www.ncbi.nlm.nih.gov/pubmed/35892585
http://dx.doi.org/10.3390/cells11152288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332277/
https://www.ncbi.nlm.nih.gov/pubmed/35892585
http://dx.doi.org/10.3390/cells11152288

Ejemplares similares