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Neutrophil Elastase Increases Vascular Permeability and Leukocyte Transmigration in Cultured Endothelial Cells and Obese Mice

Neutrophil elastase (NE) plays a pivotal role in inflammation. However, the mechanism underlying NE-mediated inflammation in obesity remains unclear. Here, we report that NE activates protease-activated receptor-2 (PAR2), stimulates actin filament (F-actin) formation, decreases intercellular junctio...

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Detalles Bibliográficos
Autores principales:	Ushakumari, Chinchu Jagadan, Zhou, Qiong L., Wang, Yu-Hua, Na, Sijia, Rigor, Michael C., Zhou, Cindy Y., Kroll, Max K., Lin, Benjamin D., Jiang, Zhen Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332277/ https://www.ncbi.nlm.nih.gov/pubmed/35892585 http://dx.doi.org/10.3390/cells11152288

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