Regioselective Synthesis of 5- and 3-Hydroxy-N-Aryl-1H-Pyrazole-4-Carboxylates and Their Evaluation as Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase

In silico evaluation of various regioisomeric 5- and 3-hydroxy-substituted alkyl 1-aryl-1H-pyrazole-4-carboxylates and their acyclic precursors yielded promising results with respect to their binding in the active site of dihydroorotate dehydrogenase of Plasmodium falciparum (PfDHODH). Consequently,...

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Detalles Bibliográficos
Autores principales: Vah, Luka, Medved, Tadej, Grošelj, Uroš, Klemenčič, Marina, Podlipnik, Črtomir, Štefane, Bogdan, Wagger, Jernej, Novinec, Marko, Svete, Jurij
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332393/
https://www.ncbi.nlm.nih.gov/pubmed/35897941
http://dx.doi.org/10.3390/molecules27154764

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332393/
https://www.ncbi.nlm.nih.gov/pubmed/35897941
http://dx.doi.org/10.3390/molecules27154764

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