The time-dependent effects of St John’s wort on cytochrome P450, uridine diphosphate-glucuronosyltransferase, glutathione S-transferase, and NAD(P)H-quinone oxidoreductase in mice

Hypericum perforatum [St. John’s wort (SJW)] is known to cause a drug interaction with the substrates of cytochrome P450 (P450, CYP) isoforms, mainly CYP3A. This study aims to determine the dose response and time course of the effects of SJW extract on P450s, UDP-glucuronosyltransferase (UGT), gluta...

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Detalles Bibliográficos
Autores principales: Yang, Jin-Fu, Liu, Yue-Rong, Huang, Chiung-Chiao, Ueng, Yune-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taiwan Food and Drug Administration 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332643/
https://www.ncbi.nlm.nih.gov/pubmed/29389584
http://dx.doi.org/10.1016/j.jfda.2017.01.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332643/
https://www.ncbi.nlm.nih.gov/pubmed/29389584
http://dx.doi.org/10.1016/j.jfda.2017.01.004

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