Detection of lithospermate B in rat plasma at the nanogram level by LC/MS in multi reaction monitoring mode

Low bioavailability and high binding affinity to plasma proteins led to the difficulty for the quantitative detection of lithospermate B (LSB) in plasma. This study aimed to develop a protocol for detecting LSB in plasma. A method was employed to quantitatively detect LSB of 5–500 ng/mL by LC/MS spe...

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Detalles Bibliográficos
Autores principales: Chung, Tse-Yu, Lin, Nan-Hei, Li, Yue-Chiun, Chen, Tzu-Yin, Kuo, Ping-Chung, Chen, Wen-Ying, Tzen, Jason T.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taiwan Food and Drug Administration 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332659/
https://www.ncbi.nlm.nih.gov/pubmed/29389574
http://dx.doi.org/10.1016/j.jfda.2017.06.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332659/
https://www.ncbi.nlm.nih.gov/pubmed/29389574
http://dx.doi.org/10.1016/j.jfda.2017.06.003

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