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Detection of lithospermate B in rat plasma at the nanogram level by LC/MS in multi reaction monitoring mode
Low bioavailability and high binding affinity to plasma proteins led to the difficulty for the quantitative detection of lithospermate B (LSB) in plasma. This study aimed to develop a protocol for detecting LSB in plasma. A method was employed to quantitatively detect LSB of 5–500 ng/mL by LC/MS spe...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taiwan Food and Drug Administration
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332659/ https://www.ncbi.nlm.nih.gov/pubmed/29389574 http://dx.doi.org/10.1016/j.jfda.2017.06.003 |