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COX-2/sEH Dual Inhibitor Alleviates Hepatocyte Senescence in NAFLD Mice by Restoring Autophagy through Sirt1/PI3K/AKT/mTOR

We previously found that the disorder of soluble epoxide hydrolase (sEH)/cyclooxygenase-2 (COX-2)-mediated arachidonic acid (ARA) metabolism contributes to the pathogenesis of the non-alcoholic fatty liver disease (NAFLD) in mice. However, the exact mechanism has not been elucidated. Accumulating ev...

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Detalles Bibliográficos
Autores principales:	Zhang, Chen-Yu, Tan, Xiao-Hua, Yang, Hui-Hui, Jin, Ling, Hong, Jie-Ru, Zhou, Yong, Huang, Xiao-Ting
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332821/ https://www.ncbi.nlm.nih.gov/pubmed/35897843 http://dx.doi.org/10.3390/ijms23158267

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