Cargando…

Prognostic impact of PDGFRA gain/amplification and MGMT promoter methylation status in patients with IDH wild-type glioblastoma

BACKGROUND: Platelet-derived growth factor receptor alpha (PDGFRA) is the second most frequently mutated tyrosine kinase receptor in glioblastoma (GBM). However, the prognostic impact of PDGFRA amplification on GBM patients remains unclear. Herein, we evaluated this impact by retrospectively analyzi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Higa, Nayuta, Akahane, Toshiaki, Yokoyama, Seiya, Yonezawa, Hajime, Uchida, Hiroyuki, Takajo, Tomoko, Otsuji, Ryosuke, Hamada, Taiji, Matsuo, Kei, Kirishima, Mari, Hata, Nobuhiro, Hanaya, Ryosuke, Tanimoto, Akihide, Yoshimoto, Koji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Basic and Translational Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332894/ https://www.ncbi.nlm.nih.gov/pubmed/35911637 http://dx.doi.org/10.1093/noajnl/vdac097

Ejemplares similares

Distribution and favorable prognostic implication of genomic EGFR alterations in IDH ‐wildtype glioblastoma
por: Higa, Nayuta, et al.
Publicado: (2022)

Alterations in EGFR and PDGFRA are associated with the localization of contrast-enhancing lesions in glioblastoma
por: Makino, Ryutaro, et al.
Publicado: (2023)

Favorable prognostic impact of phosphatase and tensin homolog alterations in wild-type isocitrate dehydrogenase and telomerase reverse transcriptase promoter glioblastoma
por: Higa, Nayuta, et al.
Publicado: (2023)

A tailored next‐generation sequencing panel identified distinct subtypes of wildtype IDH and TERT promoter glioblastomas
por: Higa, Nayuta, et al.
Publicado: (2020)

Molecular Genetic Profile of 300 Japanese Patients with Diffuse Gliomas Using a Glioma-tailored Gene Panel
por: HIGA, Nayuta, et al.
Publicado: (2022)

An oncogenic splice variant of PDGFRα in adult glioblastoma as a therapeutic target for selective CDK4/6 inhibitors
por: Hamada, Taiji, et al.
Publicado: (2022)

Genome Editing Using Cas9 Ribonucleoprotein Is Effective for Introducing PDGFRA Variant in Cultured Human Glioblastoma Cell Lines
por: Hamada, Taiji, et al.
Publicado: (2022)

MPC-18 CATEGORIZATION OF LOWER GRADE GLIOMA USING ONCOPANEL
por: Uchida, Hiroyuki, et al.
Publicado: (2019)

MPC-15 FEASIBILITY OF GLIOMA SPECIFIC ONCOPANEL IN THE DIAGNOSIS OF GLIOMA
por: Yoshimoto, Koji, et al.
Publicado: (2019)

Pilocytic Astrocytoma Presenting with Spontaneous Cerebellar Hemorrhage: A Case Report
por: YAMANAKA, Sae, et al.
Publicado: (2023)

Difficult differential diagnosis of ectopic germinoma from multiple sclerosis: A case report and literature review
por: Masuda, Keisuke, et al.
Publicado: (2023)

Combined Transcranial-supraorbital and Transconjunctival Approach for Optic Nerve Coloboma with Ophthalmic Dysplasia Associated with Rheumatoid Arthritis
por: Hanada, Tomoko, et al.
Publicado: (2019)

Patients of idiopathic normal-pressure hydrocephalus have small dural sac in cervical and upper thoracic levels: A supposed causal association
por: Kawahara, Takashi, et al.
Publicado: (2023)

MALAT1 functions as a transcriptional promoter of MALAT1::GLI1 fusion for truncated GLI1 protein expression in cancer
por: Hamada, Taiji, et al.
Publicado: (2023)

Gallbladder microbiota composition is associated with pancreaticobiliary and gallbladder cancer prognosis
por: Kirishima, Mari, et al.
Publicado: (2022)

Dural sac shrinkage signs on spinal magnetic resonance imaging indicate overdrainage after lumboperitoneal shunt for idiopathic normal pressure hydrocephalus
por: Kawahara, Takashi, et al.
Publicado: (2022)

Differentiating primary central nervous system lymphoma from glioblastoma by time-dependent diffusion using oscillating gradient
por: Kamimura, Kiyohisa, et al.
Publicado: (2023)

LGG-20. CLINICAL FEATURES AND TREATMENT RESULTS FOR PEDIATRIC OPTICO-HYPOTHALAMIC ASTROCYTOMA
por: Yoshimoto, Koji, et al.
Publicado: (2020)

Paravertebral Cerebrospinal Fluid Exudation in Young Women with Postdural Puncture Headache: A Hypothetical Interpretation based on Anatomical Study on Intervertebral Foramen
por: Kawahara, Takashi, et al.
Publicado: (2023)

Clinical significance of CDKN2A homozygous deletion in combination with methylated MGMT status for IDH‐wildtype glioblastoma
por: Funakoshi, Yusuke, et al.
Publicado: (2021)

Comprehensive validation of liquid-based cytology specimens for next-generation sequencing in cancer genome analysis
por: Akahane, Toshiaki, et al.
Publicado: (2019)

A sellar neuroblastoma showing rapid growth and causing syndrome of inappropriate secretion of antidiuretic hormone: A case report
por: Kamil, Muhammad, et al.
Publicado: (2020)

GEN-10 WHOLE GENOME LANDSCAPE OF GLIOBLASTOMA, IDH-WILD TYPE
por: Nakashima, Takuma, et al.
Publicado: (2022)

The collagen matrix dural substitute graft prevents postoperative cerebrospinal fluid leakage after ventriculoperitoneal shunt surgery in patients aged <1 year
por: Sato, Masanori, et al.
Publicado: (2022)

COT-14 CLINICAL FEATURES OF PEDIATRIC CENTRAL NERVOUS SYSTEM TUMORS
por: Higa, Nayuta, et al.
Publicado: (2019)

HGG-42. CLINICAL FEATURES AND TREATMENT OUTCOME OF MALIGNANT GLIOMAS IN CHILDREN AND ADOLESCENTS
por: Yonezawa, Hajime, et al.
Publicado: (2020)

RARE-04. INTELLECTUAL DEVELOPMENT IN CHILDREN WITH PEDIATRIC CRANIOPHARYNGIOMA AFTER TUMOR REMOVAL
por: Oyoshi, Tatsuki, et al.
Publicado: (2020)

LGG-32. CLINICAL OUTCOME OF PEDIATRIC GLIOMAS IN SINGLE INSTITUTION
por: Uchida, Hiroyuki, et al.
Publicado: (2020)

GEN-9 WHOLE GENOME SEQUENCING ANALYSIS REVEALS STRUCTURAL VARIANTS CONTRIBUTE TO TUMOR EVOLUTION IN IDH-MUTANT GLIOMA
por: Funakoshi, Yusuke, et al.
Publicado: (2022)

TET1-mediated DNA hypomethylation regulates the expression of MUC4 in lung cancer
por: Yokoyama, Seiya, et al.
Publicado: (2017)

IDH mutation and MGMT promoter methylation in glioblastoma: results of a prospective registry
por: Yang, Pei, et al.
Publicado: (2015)

Predictive MGMT status in a homogeneous cohort of IDH wildtype glioblastoma patients
por: Radke, Josefine, et al.
Publicado: (2019)

The Impact of Surgery in IDH 1 Wild Type Glioblastoma in Relation With the MGMT Deregulation
por: Marchi, Francesco, et al.
Publicado: (2020)

Formin-like 1 (FMNL1) Is Associated with Glioblastoma Multiforme Mesenchymal Subtype and Independently Predicts Poor Prognosis
por: Higa, Nayuta, et al.
Publicado: (2019)

Protective Effects of Peroxiredoxin 4 (PRDX4) on Cholestatic Liver Injury
por: Zhang, Jing, et al.
Publicado: (2018)

Prognosis of Glioblastoma With Oligodendroglioma Component is Associated With the IDH1 Mutation and MGMT Methylation Status()
por: Myung, Jae Kyung, et al.
Publicado: (2014)

XGBoost Improves Classification of MGMT Promoter Methylation Status in IDH1 Wildtype Glioblastoma
por: Le, Nguyen Quoc Khanh, et al.
Publicado: (2020)

Predictive value of MGMT promoter methylation on the survival of TMZ treated IDH-mutant glioblastoma
por: Chai, Ruichao, et al.
Publicado: (2021)

High filamin-C expression predicts enhanced invasiveness and poor outcome in glioblastoma multiforme
por: Kamil, Muhammad, et al.
Publicado: (2019)

Genetic alterations that deregulate RB and PDGFRA signaling pathways drive tumor progression in IDH2-mutant astrocytoma
por: Tateishi, Kensuke, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_a6i34u7ks44pup7naptlebv2cc