Optogenetic Reporters Delivered as mRNA Facilitate Repeatable Action Potential and Calcium Handling Assessment in Human iPSC-Derived Cardiomyocytes

Electrical activity and intracellular Ca(2+) transients are key features of cardiomyocytes. They can be measured using organic voltage- and Ca(2+)-sensitive dyes but their photostability and phototoxicity mean they are unsuitable for long-term measurements. Here, we investigated whether genetically...

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Detalles Bibliográficos
Autores principales: Yiangou, Loukia, Blanch-Asensio, Albert, de Korte, Tessa, Miller, Duncan C, van Meer, Berend J, Mol, Mervyn P H, van den Brink, Lettine, Brandão, Karina O, Mummery, Christine L, Davis, Richard P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Embryonic Stem Cells/Induced Pluripotent Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332902/
https://www.ncbi.nlm.nih.gov/pubmed/35429386
http://dx.doi.org/10.1093/stmcls/sxac029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332902/
https://www.ncbi.nlm.nih.gov/pubmed/35429386
http://dx.doi.org/10.1093/stmcls/sxac029

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