Integrated Multilayer Omics Reveals the Genomic, Proteomic, and Metabolic Influences of Histidyl Dipeptides on the Heart

BACKGROUND: Histidyl dipeptides such as carnosine are present in a micromolar to millimolar range in mammalian hearts. These dipeptides facilitate glycolysis by proton buffering. They form conjugates with reactive aldehydes, such as acrolein, and attenuate myocardial ischemia–reperfusion injury. Alt...

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Detalles Bibliográficos
Autores principales: Yan, Keqiang, Mei, Zhanlong, Zhao, Jingjing, Prodhan, Md Aminul Islam, Obal, Detlef, Katragadda, Kartik, Doelling, Benjamin, Hoetker, David, Posa, Dheeraj Kumar, He, Liqing, Yin, Xinmin, Shah, Jasmit, Pan, Jianmin, Rai, Shesh, Lorkiewicz, Pawel Konrad, Zhang, Xiang, Liu, Siqi, Bhatnagar, Aruni, Baba, Shahid P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333374/
https://www.ncbi.nlm.nih.gov/pubmed/35730646
http://dx.doi.org/10.1161/JAHA.121.023868

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333374/
https://www.ncbi.nlm.nih.gov/pubmed/35730646
http://dx.doi.org/10.1161/JAHA.121.023868

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