Enhancing and inhibitory motifs regulate CD4 activity

CD4(+) T cells use T cell receptor (TCR)–CD3 complexes, and CD4, to respond to peptide antigens within MHCII molecules (pMHCII). We report here that, through ~435 million years of evolution in jawed vertebrates, purifying selection has shaped motifs in the extracellular, transmembrane, and intracell...

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Detalles Bibliográficos
Autores principales: Lee, Mark S, Tuohy, Peter J, Kim, Caleb Y, Lichauco, Katrina, Parrish, Heather L, Van Doorslaer, Koenraad, Kuhns, Michael S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333989/
https://www.ncbi.nlm.nih.gov/pubmed/35861317
http://dx.doi.org/10.7554/eLife.79508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333989/
https://www.ncbi.nlm.nih.gov/pubmed/35861317
http://dx.doi.org/10.7554/eLife.79508

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