The lupus susceptibility allele DRB1*03:01 encodes a disease-driving epitope

The HLA-DRB1*03:01 allele is a major genetic risk factor in systemic lupus erythematosus (SLE), but the mechanistic basis of the association is unclear. Here we show that in the presence of interferon gamma (IFN-γ), a short DRB1*03:01-encoded allelic epitope activates a characteristic lupus transcri...

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Detalles Bibliográficos
Autores principales: Miglioranza Scavuzzi, Bruna, van Drongelen, Vincent, Kaur, Bhavneet, Fox, Jennifer Callahan, Liu, Jianhua, Mesquita-Ferrari, Raquel A., Kahlenberg, J. Michelle, Farkash, Evan A., Benavides, Fernando, Miller, Frederick W., Sawalha, Amr H., Holoshitz, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334592/
https://www.ncbi.nlm.nih.gov/pubmed/35902632
http://dx.doi.org/10.1038/s42003-022-03717-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334592/
https://www.ncbi.nlm.nih.gov/pubmed/35902632
http://dx.doi.org/10.1038/s42003-022-03717-x

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