Fusion protein strategies for cryo-EM study of G protein-coupled receptors

Single particle cryogenic-electron microscopy (cryo-EM) is used extensively to determine structures of activated G protein-coupled receptors (GPCRs) in complex with G proteins or arrestins. However, applying it to GPCRs without signaling proteins remains challenging because most receptors lack struc...

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Detalles Bibliográficos
Autores principales: Zhang, Kaihua, Wu, Hao, Hoppe, Nicholas, Manglik, Aashish, Cheng, Yifan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334595/
https://www.ncbi.nlm.nih.gov/pubmed/35902590
http://dx.doi.org/10.1038/s41467-022-32125-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334595/
https://www.ncbi.nlm.nih.gov/pubmed/35902590
http://dx.doi.org/10.1038/s41467-022-32125-2

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