Cargando…

The hexokinase “HKDC1” interaction with the mitochondria is essential for liver cancer progression

Liver cancer (LC) is the fourth leading cause of death from cancer malignancies. Recently, a putative fifth hexokinase, hexokinase domain containing 1 (HKDC1), was shown to have significant overexpression in LC compared to healthy liver tissue. Using a combination of in vitro and in vivo tools, we e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khan, Md. Wasim, Terry, Alexander R., Priyadarshini, Medha, Ilievski, Vladimir, Farooq, Zeenat, Guzman, Grace, Cordoba-Chacon, Jose, Ben-Sahra, Issam, Wicksteed, Barton, Layden, Brian T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334634/ https://www.ncbi.nlm.nih.gov/pubmed/35902556 http://dx.doi.org/10.1038/s41419-022-04999-z

Ejemplares similares

Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity
por: Pusec, Carolina M., et al.
Publicado: (2023)

Enterocyte HKDC1 Modulates Intestinal Glucose Absorption in Male Mice Fed a High-fat Diet
por: Zapater, Joseph L, et al.
Publicado: (2022)

Aiding Cancer’s “Sweet Tooth”: Role of Hexokinases in Metabolic Reprogramming
por: Farooq, Zeenat, et al.
Publicado: (2023)

Coordinated Regulatory Variation Associated with Gestational Hyperglycemia Regulates Expression of the Novel Hexokinase HKDC1
por: Guo, Cong, et al.
Publicado: (2015)

RF04 | PSUN297 Genetic Knockout of Intestinal Hexokinase Domain Containing Protein-1 Affects Enterocyte Glucose Transport in Mice Fed High Fat Diet
por: Zapater, Joseph, et al.
Publicado: (2022)

FFAR from the Gut Microbiome Crowd: SCFA Receptors in T1D Pathology
por: Priyadarshini, Medha, et al.
Publicado: (2021)

OR23-4 Intestinal FFA2 and FFA3 Mediate Obesogenic Effects in Mice on a Western Diet
por: Gough, Sophie, et al.
Publicado: (2022)

PSUN82 The Gut Microbiome Regulates Healthy Adipose Tissue Expansion via the Action of FFA2
por: Nnyamah, Christine, et al.
Publicado: (2022)

FRI012 Exploring The Role Of FFA2 In Western Diet-induced Obesity And Metabolic Changes
por: Nnyamah, Christine, et al.
Publicado: (2023)

MON-642 Genetic Knockout of Intestinal Hexokinase Domain-Containing Protein 1 Affects Whole-Body Glycemic Control and Triglyceride Metabolism
por: Zapater, Joseph Louis, et al.
Publicado: (2020)

Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity
por: Yamamoto, Soh, et al.
Publicado: (2018)

Hexokinases inhibit death receptor–dependent apoptosis on the mitochondria
por: Lauterwasser, Joachim, et al.
Publicado: (2021)

HKDC1 Silencing Inhibits Proliferation and Glycolysis of Gastric Cancer Cells
por: Yu, Chen, et al.
Publicado: (2023)

FRI013 Free Fatty Acid Receptors 2 And 3 Mediate The Beneficial Effects Of Fiber
por: Pandya, Nupur S, et al.
Publicado: (2023)

A study on the two binding sites of hexokinase on brain mitochondria
por: Golestani, Abolfazl, et al.
Publicado: (2007)

Amyloid-β Triggers the Release of Neuronal Hexokinase 1 from Mitochondria
por: Saraiva, Leonardo M., et al.
Publicado: (2010)

Identification of HKDC1 and BACE2 as Genes Influencing Glycemic Traits During Pregnancy Through Genome-Wide Association Studies
por: Hayes, M. Geoffrey, et al.
Publicado: (2013)

Modulation of hexokinase association with mitochondria analyzed with quantitative three-dimensional confocal microscopy
Publicado: (1991)

PKA Enhances the Acute Insulin Response Leading to the Restoration of Glucose Control
por: Kaihara, Kelly A., et al.
Publicado: (2015)

Loss of Intestine-Specific FFA3 Has Protective Effects Against Diet-Induced Obesity and Hyperglycemia in Mice on a Western Diet
por: Lednovich, Kristen Roan, et al.
Publicado: (2021)

Identification of a periodontal pathogen and bihormonal cells in pancreatic islets of humans and a mouse model of periodontitis
por: Ilievski, Vladimir, et al.
Publicado: (2020)

HKDC1 upregulation promotes glycolysis and disease progression, and confers chemoresistance onto gastric cancer
por: Wang, Mei‐Qian, et al.
Publicado: (2023)

SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis
por: Shangguan, Xun, et al.
Publicado: (2021)

FFA2 Contribution to Gestational Glucose Tolerance Is Not Disrupted by Antibiotics
por: Fuller, Miles, et al.
Publicado: (2016)

Hexokinase II–derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells
por: Woldetsadik, Abiy D., et al.
Publicado: (2017)

Hexokinase and Glucokinases Are Essential for Fitness and Virulence in the Pathogenic Yeast Candida albicans
por: Laurian, Romain, et al.
Publicado: (2019)

Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies. Diabetes 2013;62:3282–3291
por: Hayes, MG, et al.
Publicado: (2013)

PGC1β Regulates Breast Tumor Growth and Metastasis by SREBP1-Mediated HKDC1 Expression
por: Chen, Xiaoli, et al.
Publicado: (2019)

HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway
por: Wang, Xinyu, et al.
Publicado: (2020)

New Insights Into Gestational Glucose Metabolism: Lessons Learned From 21st Century Approaches
por: Angueira, Anthony R., et al.
Publicado: (2015)

Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin
por: DeWaal, Dannielle, et al.
Publicado: (2018)

High glucose induces apoptosis of HUVECs in a mitochondria-dependent manner by suppressing hexokinase 2 expression
por: Zhang, Jia, et al.
Publicado: (2019)

Hexokinase 2 as oncotarget
por: Patra, Krushna C., et al.
Publicado: (2013)

SAT073 β Cell FFA2 Deficiency Suppresses Multiple Low Dose Streptozotocin (MLDS) Induced Diabetes
por: Xu, Kai, et al.
Publicado: (2023)

Author Correction: Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin
por: DeWaal, Dannielle, et al.
Publicado: (2018)

Inorganic Polyphosphates Regulate Hexokinase Activity and Reactive Oxygen Species Generation in Mitochondria of Rhipicephalus (Boophilus) microplus Embryo
por: Fraga, Amanda, et al.
Publicado: (2013)

Hexokinase 2 displacement from mitochondria‐associated membranes prompts Ca(2+)‐dependent death of cancer cells
por: Ciscato, Francesco, et al.
Publicado: (2020)

Detachment of Hexokinase II From Mitochondria Promotes Collateral Sensitivity in Multidrug Resistant Chronic Myeloid Leukemia Cells
por: Oliveira, Thaís, et al.
Publicado: (2022)

Implication of KRT16, FAM129A and HKDC1 genes as ATF4 regulated components of the integrated stress response
por: Evstafieva, Alexandra G., et al.
Publicado: (2018)

The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer
por: Fuhr, Luise, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_p8jo4js5k1o9b978hcsll58e4m