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Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C

NK cells play a pivotal role in viral immunity, utilizing a large array of activating and inhibitory receptors to identify and eliminate virus-infected cells. Killer-cell immunoglobulin-like receptors (KIRs) represent a highly polymorphic receptor family, regulating NK cell activity and determining...

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Detalles Bibliográficos
Autores principales: Vollmers, Sarah, Lobermeyer, Annabelle, Niehrs, Annika, Fittje, Pia, Indenbirken, Daniela, Nakel, Jacqueline, Virdi, Sanamjeet, Brias, Sebastien, Trenkner, Timo, Sauer, Gabriel, Peine, Sven, Behrens, Georg M.N., Lehmann, Clara, Meurer, Anja, Pauli, Ramona, Postel, Nils, Roider, Julia, Scholten, Stefan, Spinner, Christoph D., Stephan, Christoph, Wolf, Eva, Wyen, Christoph, Richert, Laura, Norman, Paul J., Sauter, Jürgen, Schmidt, Alexander H., Hoelzemer, Angelique, Altfeld, Marcus, Körner, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334850/
https://www.ncbi.nlm.nih.gov/pubmed/35911762
http://dx.doi.org/10.3389/fimmu.2022.922252