Sorting nexin 24 is required for α-granule biogenesis and cargo delivery in megakaryocytes

Germline defects affecting the DNA-binding domain of the transcription factor FLI1 are associated with a bleeding disorder that is characterized by the presence of large, fused α-granules in platelets. We investigated whether the genes showing abnormal expression in FLI1-deficient platelets could be...

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Detalles Bibliográficos
Autores principales: Lacey, Joanne, Webster, Simon J., Heath, Paul R., Hill, Chris J., Nicholson-Goult, Lucinda, Wagner, Bart E., Khan, Abdullah O., Morgan, Neil V., Makris, Michael, Daly, Martina E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2022
Materias:
Article - Platelet Biology & its Disorders
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335091/
https://www.ncbi.nlm.nih.gov/pubmed/35021601
http://dx.doi.org/10.3324/haematol.2021.279636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335091/
https://www.ncbi.nlm.nih.gov/pubmed/35021601
http://dx.doi.org/10.3324/haematol.2021.279636

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