Syntaxin 5 determines Weibel-Palade body size and von Willebrand factor secretion by controlling Golgi architecture

von Willebrand factor (VWF) is a multimeric hemostatic protein primarily synthesized in endothelial cells. VWF is stored in endothelial storage organelles, the Weibel-Palade bodies (WPB), whose biogenesis strongly depends on VWF anterograde trafficking and Golgi architecture. Elongated WPB morpholog...

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Detalles Bibliográficos
Autores principales: Kat, Marije, Karampini, Ellie, Hoogendijk, Arie J., Bürgisser, Petra E., Mulder, Aat A., van Alphen, Floris P.J., Olins, Jenny, Geerts, Dirk, van den Biggelaar, Maartje, Margadant, Coert, Voorberg, Jan, Bierings, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2022
Materias:
Article - Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335113/
https://www.ncbi.nlm.nih.gov/pubmed/35081689
http://dx.doi.org/10.3324/haematol.2021.280121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335113/
https://www.ncbi.nlm.nih.gov/pubmed/35081689
http://dx.doi.org/10.3324/haematol.2021.280121

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