De novo design of protein homodimers containing tunable symmetric protein pockets

Function follows form in biology, and the binding of small molecules requires proteins with pockets that match the shape of the ligand. For design of binding to symmetric ligands, protein homo-oligomers with matching symmetry are advantageous as each protein subunit can make identical interactions w...

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Detalles Bibliográficos
Autores principales: Hicks, Derrick R., Kennedy, Madison A., Thompson, Kirsten A., DeWitt, Michelle, Coventry, Brian, Kang, Alex, Bera, Asim K., Brunette, T. J., Sankaran, Banumathi, Stoddard, Barry, Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335249/
https://www.ncbi.nlm.nih.gov/pubmed/35862457
http://dx.doi.org/10.1073/pnas.2113400119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335249/
https://www.ncbi.nlm.nih.gov/pubmed/35862457
http://dx.doi.org/10.1073/pnas.2113400119

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