Probing Watson-Crick and Hoogsteen base pairing in duplex DNA using dynamic nuclear polarization solid-state NMR spectroscopy

The majority of base pairs in double-stranded DNA exist in the canonical Watson-Crick geometry. However, they can also adopt alternate Hoogsteen conformations in various complexes of DNA with proteins and small molecules, which are key for biological function and mechanism. While detection of Hoogst...

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Detalles Bibliográficos
Autores principales: Conroy, Daniel W., Xu, Yu, Shi, Honglue, Gonzalez Salguero, Nicole, Purusottam, Rudra N., Shannon, Matthew D., Al-Hashimi, Hashim M., Jaroniec, Christopher P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Physical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335254/
https://www.ncbi.nlm.nih.gov/pubmed/35857870
http://dx.doi.org/10.1073/pnas.2200681119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335254/
https://www.ncbi.nlm.nih.gov/pubmed/35857870
http://dx.doi.org/10.1073/pnas.2200681119

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