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Probing Watson-Crick and Hoogsteen base pairing in duplex DNA using dynamic nuclear polarization solid-state NMR spectroscopy
The majority of base pairs in double-stranded DNA exist in the canonical Watson-Crick geometry. However, they can also adopt alternate Hoogsteen conformations in various complexes of DNA with proteins and small molecules, which are key for biological function and mechanism. While detection of Hoogst...
Autores principales: | Conroy, Daniel W., Xu, Yu, Shi, Honglue, Gonzalez Salguero, Nicole, Purusottam, Rudra N., Shannon, Matthew D., Al-Hashimi, Hashim M., Jaroniec, Christopher P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335254/ https://www.ncbi.nlm.nih.gov/pubmed/35857870 http://dx.doi.org/10.1073/pnas.2200681119 |
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