Targeted deubiquitination rescues distinct trafficking-deficient ion channelopathies

Impaired protein stability/trafficking underlies diverse ion channelopathies and represents an unexploited unifying principle to develop common treatments for otherwise dissimilar diseases. Ubiquitination limits ion channel surface density, but targeting this pathway for basic study or therapy is ch...

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Detalles Bibliográficos
Autores principales: Kanner, Scott A., Shuja, Zunaira, Choudhury, Papiya, Jain, Ananya, Colecraft, Henry M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335257/
https://www.ncbi.nlm.nih.gov/pubmed/33169015
http://dx.doi.org/10.1038/s41592-020-00992-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335257/
https://www.ncbi.nlm.nih.gov/pubmed/33169015
http://dx.doi.org/10.1038/s41592-020-00992-6

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