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Proton transfer activity of the reconstituted Mycobacterium tuberculosis MmpL3 is modulated by substrate mimics and inhibitors

Transporters belonging to the Resistance-Nodulation-cell Division (RND) superfamily of proteins such as Mycobacterium tuberculosis MmpL3 and its analogs are the focus of intense investigations due to their importance in the physiology of Corynebacterium–Mycobacterium–Nocardia species and antimycobac...

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Detalles Bibliográficos
Autores principales: Stevens, Casey M., Babii, Svitlana O., Pandya, Amitkumar N., Li, Wei, Li, Yupeng, Mehla, Jitender, Scott, Robyn, Hegde, Pooja, Prathipati, Pavan K., Acharya, Atanu, Liu, Jinchan, Gumbart, James C., North, Jeffrey, Jackson, Mary, Zgurskaya, Helen I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335285/
https://www.ncbi.nlm.nih.gov/pubmed/35858440
http://dx.doi.org/10.1073/pnas.2113963119