Structural basis for high-voltage activation and subtype-specific inhibition of human Na(v)1.8

The dorsal root ganglia–localized voltage-gated sodium (Na(v)) channel Na(v)1.8 represents a promising target for developing next-generation analgesics. A prominent characteristic of Na(v)1.8 is the requirement of more depolarized membrane potential for activation. Here we present the cryogenic elec...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Xiaoshuang, Jin, Xueqin, Huang, Gaoxingyu, Huang, Jian, Wu, Tong, Li, Zhangqiang, Chen, Jiaofeng, Kong, Fang, Pan, Xiaojing, Yan, Nieng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335304/
https://www.ncbi.nlm.nih.gov/pubmed/35858452
http://dx.doi.org/10.1073/pnas.2208211119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335304/
https://www.ncbi.nlm.nih.gov/pubmed/35858452
http://dx.doi.org/10.1073/pnas.2208211119

Ejemplares similares