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Structural basis for high-voltage activation and subtype-specific inhibition of human Na(v)1.8
The dorsal root ganglia–localized voltage-gated sodium (Na(v)) channel Na(v)1.8 represents a promising target for developing next-generation analgesics. A prominent characteristic of Na(v)1.8 is the requirement of more depolarized membrane potential for activation. Here we present the cryogenic elec...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335304/ https://www.ncbi.nlm.nih.gov/pubmed/35858452 http://dx.doi.org/10.1073/pnas.2208211119 |