Elevated intracellular Na(+) and osmolarity stimulate catalytic activity of the ubiquitin ligase Nedd4-2

Regulation of catalytic activity of E3 ubiquitin ligases is critical for their cellular functions. We identified an unexpected mode of regulation of E3 catalytic activity by ions and osmolarity; enzymatic activity of the HECT family E3 Nedd4-2/Nedd4L is enhanced by increased intracellular Na(+) ([Na...

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Detalles Bibliográficos
Autores principales: Persaud, Avinash, Jiang, Chong, Liu, Zetao, Kefalas, George, Demian, Wael L., Rotin, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335340/
https://www.ncbi.nlm.nih.gov/pubmed/35858421
http://dx.doi.org/10.1073/pnas.2122495119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335340/
https://www.ncbi.nlm.nih.gov/pubmed/35858421
http://dx.doi.org/10.1073/pnas.2122495119

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