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A review of the anti-diabetic potential of saffron

Diabetes mellitus is one of the most prevalent metabolic disorders that affect people of all genders, ages, and races. Medicinal herbs have gained attention from researchers and have been widely investigated for their antidiabetic potential. Saffron (Crocus sativus L.) and its main constituents, tha...

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Autores principales: Sani, Anis, Tajik, Ali, Seiiedi, Seiied Sina, Khadem, Razieh, Tootooni, Haniye, Taherynejad, Mohammadhossein, Sabet Eqlidi, Nasim, Alavi dana, Seyyed mohammad matin, Deravi, Niloofar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335478/
https://www.ncbi.nlm.nih.gov/pubmed/35911474
http://dx.doi.org/10.1177/11786388221095223
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author Sani, Anis
Tajik, Ali
Seiiedi, Seiied Sina
Khadem, Razieh
Tootooni, Haniye
Taherynejad, Mohammadhossein
Sabet Eqlidi, Nasim
Alavi dana, Seyyed mohammad matin
Deravi, Niloofar
author_facet Sani, Anis
Tajik, Ali
Seiiedi, Seiied Sina
Khadem, Razieh
Tootooni, Haniye
Taherynejad, Mohammadhossein
Sabet Eqlidi, Nasim
Alavi dana, Seyyed mohammad matin
Deravi, Niloofar
author_sort Sani, Anis
collection PubMed
description Diabetes mellitus is one of the most prevalent metabolic disorders that affect people of all genders, ages, and races. Medicinal herbs have gained attention from researchers and have been widely investigated for their antidiabetic potential. Saffron (Crocus sativus L.) and its main constituents, that is, crocin and crocetin, are natural carotenoid compounds, widely known to possess a wide spectrum of properties and induce pleiotropic anti-inflammatory, anti-oxidative, and neuro-protective effects. An increasing number of experimental, animal and human studies have investigated the effects and mechanism of action of these compounds and their potential therapeutic use in the treatment of diabetes. This narrative review presents the key findings of published clinical studies that examined the effects of saffron and/or its constituents in the context of diabetes mellitus. Moreover, an overview of the proposed underlying mechanisms mediating these effects, the medicinal applications of saffron, and the new findings regarding its effect on diabetes and various cellular and molecular mechanisms of action will be debated.
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spelling pubmed-93354782022-07-30 A review of the anti-diabetic potential of saffron Sani, Anis Tajik, Ali Seiiedi, Seiied Sina Khadem, Razieh Tootooni, Haniye Taherynejad, Mohammadhossein Sabet Eqlidi, Nasim Alavi dana, Seyyed mohammad matin Deravi, Niloofar Nutr Metab Insights Review Diabetes mellitus is one of the most prevalent metabolic disorders that affect people of all genders, ages, and races. Medicinal herbs have gained attention from researchers and have been widely investigated for their antidiabetic potential. Saffron (Crocus sativus L.) and its main constituents, that is, crocin and crocetin, are natural carotenoid compounds, widely known to possess a wide spectrum of properties and induce pleiotropic anti-inflammatory, anti-oxidative, and neuro-protective effects. An increasing number of experimental, animal and human studies have investigated the effects and mechanism of action of these compounds and their potential therapeutic use in the treatment of diabetes. This narrative review presents the key findings of published clinical studies that examined the effects of saffron and/or its constituents in the context of diabetes mellitus. Moreover, an overview of the proposed underlying mechanisms mediating these effects, the medicinal applications of saffron, and the new findings regarding its effect on diabetes and various cellular and molecular mechanisms of action will be debated. SAGE Publications 2022-07-27 /pmc/articles/PMC9335478/ /pubmed/35911474 http://dx.doi.org/10.1177/11786388221095223 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Sani, Anis
Tajik, Ali
Seiiedi, Seiied Sina
Khadem, Razieh
Tootooni, Haniye
Taherynejad, Mohammadhossein
Sabet Eqlidi, Nasim
Alavi dana, Seyyed mohammad matin
Deravi, Niloofar
A review of the anti-diabetic potential of saffron
title A review of the anti-diabetic potential of saffron
title_full A review of the anti-diabetic potential of saffron
title_fullStr A review of the anti-diabetic potential of saffron
title_full_unstemmed A review of the anti-diabetic potential of saffron
title_short A review of the anti-diabetic potential of saffron
title_sort review of the anti-diabetic potential of saffron
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335478/
https://www.ncbi.nlm.nih.gov/pubmed/35911474
http://dx.doi.org/10.1177/11786388221095223
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