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A review of the anti-diabetic potential of saffron
Diabetes mellitus is one of the most prevalent metabolic disorders that affect people of all genders, ages, and races. Medicinal herbs have gained attention from researchers and have been widely investigated for their antidiabetic potential. Saffron (Crocus sativus L.) and its main constituents, tha...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335478/ https://www.ncbi.nlm.nih.gov/pubmed/35911474 http://dx.doi.org/10.1177/11786388221095223 |
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author | Sani, Anis Tajik, Ali Seiiedi, Seiied Sina Khadem, Razieh Tootooni, Haniye Taherynejad, Mohammadhossein Sabet Eqlidi, Nasim Alavi dana, Seyyed mohammad matin Deravi, Niloofar |
author_facet | Sani, Anis Tajik, Ali Seiiedi, Seiied Sina Khadem, Razieh Tootooni, Haniye Taherynejad, Mohammadhossein Sabet Eqlidi, Nasim Alavi dana, Seyyed mohammad matin Deravi, Niloofar |
author_sort | Sani, Anis |
collection | PubMed |
description | Diabetes mellitus is one of the most prevalent metabolic disorders that affect people of all genders, ages, and races. Medicinal herbs have gained attention from researchers and have been widely investigated for their antidiabetic potential. Saffron (Crocus sativus L.) and its main constituents, that is, crocin and crocetin, are natural carotenoid compounds, widely known to possess a wide spectrum of properties and induce pleiotropic anti-inflammatory, anti-oxidative, and neuro-protective effects. An increasing number of experimental, animal and human studies have investigated the effects and mechanism of action of these compounds and their potential therapeutic use in the treatment of diabetes. This narrative review presents the key findings of published clinical studies that examined the effects of saffron and/or its constituents in the context of diabetes mellitus. Moreover, an overview of the proposed underlying mechanisms mediating these effects, the medicinal applications of saffron, and the new findings regarding its effect on diabetes and various cellular and molecular mechanisms of action will be debated. |
format | Online Article Text |
id | pubmed-9335478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-93354782022-07-30 A review of the anti-diabetic potential of saffron Sani, Anis Tajik, Ali Seiiedi, Seiied Sina Khadem, Razieh Tootooni, Haniye Taherynejad, Mohammadhossein Sabet Eqlidi, Nasim Alavi dana, Seyyed mohammad matin Deravi, Niloofar Nutr Metab Insights Review Diabetes mellitus is one of the most prevalent metabolic disorders that affect people of all genders, ages, and races. Medicinal herbs have gained attention from researchers and have been widely investigated for their antidiabetic potential. Saffron (Crocus sativus L.) and its main constituents, that is, crocin and crocetin, are natural carotenoid compounds, widely known to possess a wide spectrum of properties and induce pleiotropic anti-inflammatory, anti-oxidative, and neuro-protective effects. An increasing number of experimental, animal and human studies have investigated the effects and mechanism of action of these compounds and their potential therapeutic use in the treatment of diabetes. This narrative review presents the key findings of published clinical studies that examined the effects of saffron and/or its constituents in the context of diabetes mellitus. Moreover, an overview of the proposed underlying mechanisms mediating these effects, the medicinal applications of saffron, and the new findings regarding its effect on diabetes and various cellular and molecular mechanisms of action will be debated. SAGE Publications 2022-07-27 /pmc/articles/PMC9335478/ /pubmed/35911474 http://dx.doi.org/10.1177/11786388221095223 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Sani, Anis Tajik, Ali Seiiedi, Seiied Sina Khadem, Razieh Tootooni, Haniye Taherynejad, Mohammadhossein Sabet Eqlidi, Nasim Alavi dana, Seyyed mohammad matin Deravi, Niloofar A review of the anti-diabetic potential of saffron |
title | A review of the anti-diabetic potential of saffron |
title_full | A review of the anti-diabetic potential of saffron |
title_fullStr | A review of the anti-diabetic potential of saffron |
title_full_unstemmed | A review of the anti-diabetic potential of saffron |
title_short | A review of the anti-diabetic potential of saffron |
title_sort | review of the anti-diabetic potential of saffron |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335478/ https://www.ncbi.nlm.nih.gov/pubmed/35911474 http://dx.doi.org/10.1177/11786388221095223 |
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